Does Semaglutide make you tired?

Are you experiencing fatigue while taking Semaglutide? Many patients wonder, “does Semaglutide make you tired?” Indeed, tiredness can be a side effect of this diabetes medication. Semaglutide can induce feelings of tiredness, largely due to its effects on appetite and caloric intake. This article delves into the connection between Semaglutide and fatigue, offering evidence from clinical trials and strategies for managing this potential side effect.

Key takeaways

  • Semaglutide, used for type 2 diabetes, can cause fatigue, potentially due to its appetite-suppressing effect and caloric deficit it induces, and the experience of tiredness may vary depending on whether it’s taken orally or as an injection.
  • The medication can lead to additional side effects like nausea and stomach pain, which may exacerbate fatigue; plus, it can cause low blood sugar, which requires medical attention if symptoms like tiredness occur.
  • Management strategies for Semaglutide-induced fatigue include a well-balanced diet, regular exercise, stress reduction techniques, and appropriately adjusting the medication’s dosage with healthcare provider guidance.

Exploring Semaglutide and fatigue

Does Semaglutide make you tired?

Semaglutide, a medication for managing and lowering blood sugar levels in people with type 2 diabetes, has a notable side effect – it can induce fatigue. The connection between Semaglutide and tiredness is rooted in its appetite-suppressing effects and the impact it can have on your energy levels.

Individuals commencing Semaglutide treatment may encounter fatigue, especially during the initial stages of their therapy. This tiredness should be closely monitored and discussed with a healthcare professional if it becomes persistent. Interestingly, the mode of Semaglutide administration could also influence its fatigue-inducing effects. Patients taking Semaglutide as a pill reported no significant incidence of fatigue, in contrast to those receiving it as Semaglutide injections, who did experience tiredness.

Understanding the link between Semaglutide and energy levels

Semaglutide operates by curbing your appetite, which results in reduced calorie intake. This might contribute to feelings of tiredness as your body experiences a caloric deficit. The weight loss (excess weight) associated with Semaglutide is predominantly due to decreased energy intake rather than increased energy expenditure, indicating a direct link to potential fatigue from a reduction in caloric consumption. So, does Semaglutide make you tired? It’s possible, as the reduced calorie intake may lead to feelings of fatigue.

Simply put, to eat fewer calories leaves your body with fewer resources to transform into energy, potentially leading to feelings of fatigue. This effect is even more pronounced when Semaglutide is used in combination with a reduced-calorie diet for weight loss.

Clinical trials and reported tiredness

The incidence of fatigue among trial participants varied depending on the form and dose of Semaglutide. For instance, less than 0.4% of Ozempic users reported experiencing fatigue as a side effect. However, participants in Wegovy trials taking the maximum dose of 2.4 mg reported tiredness at a rate of 11%.

Interestingly, there was no reported fatigue among patients taking Rybelsus, which is an oral form of Semaglutide. This suggests that the method of administration may influence the experience of fatigue, although more research is needed to confirm this.

Investigating the side effects: Beyond feeling tired or stomach pain

Does Semaglutide make you tired?

While some individuals taking Semaglutide may worry about fatigue, it’s worth noting that this medication can also cause other side effects. Some of these include:

  • Nausea.
  • Vomiting.
  • Stomach pain.
  • Diarrhea.
  • Constipation.
  • Abdominal distension.

These side effects can also contribute to feelings of experience fatigue and make you feel tired.

Less common gastrointestinal side effects include belching, excess gas, and heartburn, while rare side effects (rare cases) include a burning feeling in the chest or stomach and tenderness in the stomach area. However, adopting certain dietary habits, like eating lower-fat and less greasy foods, reducing or avoiding certain foods, and avoiding alcohol, can help minimize these side effects.

The role of low blood sugar in fatigue

The influence of Semaglutide on blood sugar levels is significant, with the ability to lower blood sugar levels within the first week of use. This rapid change can lead to symptoms of low blood sugar, including tiredness.

If you’re taking Semaglutide and experience symptoms of low blood sugar, it’s important to seek immediate medical attention. This is because prolonged low blood sugar can lead to more serious health complications, such as seizures or loss of consciousness.

Other factors that may cause tiredness on Semaglutide

Apart from low blood sugar, other factors can also induce fatigue in individuals taking Semaglutide. For instance, Semaglutide may increase the risk of thyroid tumors, including thyroid cancer, which if affecting thyroid function, could contribute to feelings of fatigue.

Additionally, conditions such as pancreatitis and gallbladder or gallbladder disease issues, which may arise while using Semaglutide, can also lead to increased tiredness. Even an increased heart rate at rest, a possible side effect of Semaglutide, might leave users feeling sluggish and more tired or physically exhausted.

How your body adjusts over time

Does Semaglutide make you tired?

As Semaglutide use continues, the body adapts to the medication, potentially leading to a decrease in initial fatigue symptoms over time.

However, if fatigue persists for more than a few weeks after starting Semaglutide, it’s important to consult a healthcare provider. This could be indicative of an issue that needs further investigation.

The importance of regular monitoring with your healthcare provider

Continuous monitoring by a healthcare provider is imperative for individuals taking Semaglutide. This is because any necessary adjustments in your dosage need to be made under the guidance of a healthcare provider.

Your healthcare provider can also provide guidelines on diet and lifestyle changes to help manage any side effects. This is particularly important as these changes can improve your treatment adherence and persistence, ultimately leading to better overall health outcomes.

Balancing diet and Semaglutide treatment

A balanced diet is vital in mitigating the side effects of Semaglutide, such as fatigue. By consuming a diet full of fiber, protein, and healthy carbohydrates, you can help maximize the benefits of Semaglutide treatment and avoid side effects like fatigue.

It’s also important to manage your intake of alcohol and exercise to prevent low blood sugar, which can lead to tiredness. Working with a dietitian can help you create a tailored nutritional plan, which along with taking Semaglutide with food and drinking plenty of water, can help manage weight, energy levels, and minimize potential side effects.

Strategies to maintain energy levels while losing body weight

Does Semaglutide make you tired?

While losing weight on Semaglutide, maintaining energy levels can be a challenging equilibrium to achieve. For instance, consuming complex carbohydrates that are high in fiber can help maintain energy levels by releasing glucose into the bloodstream steadily, which contributes to blood sugar control.

Eating nutrient-rich fruits and vegetables as part of a balanced and nutritious diet can also enhance satiety and provide essential nutrients for energy production. Additionally, adding protein to meals can prevent post-meal blood sugar spikes and overeating by enhancing the feeling of fullness.

Does Semaglutide make you tired?

Interactions with other medications and nutritional supplements

Awareness of potential interactions between Semaglutide and other many medications or nutritional supplements is essential. For instance, Semaglutide can contribute to hypoglycemia when used with other diabetes medications that also lower blood glucose levels.

It’s also crucial to avoid over-the-counter medications that may interact with Semaglutide, unless a healthcare provider has been consulted. Additionally, supplementing with Vitamin B12 can improve energy levels and blood glucose control whilst on Semaglutide treatment.

Lifestyle modifications to combat Semaglutide-induced fatigue

Lifestyle changes can be instrumental in managing fatigue induced by Semaglutide. Some strategies to consider include:

  • Catching up on lost sleep.
  • Maintaining a balanced diet.
  • Stay hydrated.
  • Engaging in gentle exercise.

These changes can help manage fatigue and increase overall energy levels.

In addition, getting enough sleep, such as by lowering sleep debt and syncing up with circadian rhythms, can also enhance energy levels and help manage fatigue associated with Semaglutide.

The impact of physical activity on energy and weight loss management

Does Semaglutide make you tired?

Engaging in physical activity is another crucial element in mitigating fatigue caused by Semaglutide. Exercise not only increases energy levels and overall vitality, which can help counteract any fatigue experienced as a side effect of Semaglutide, it also plays a critical role in weight management. Some types of physical activity that can be beneficial include:

  • Walking or jogging.
  • Cycling.
  • Swimming.
  • Yoga or Pilates.
  • Strength training.

Incorporating regular exercise into your routine can help improve your overall well-being and reduce fatigue.

Taking a walk after meals can help with gastrointestinal symptoms and increase overall energy levels. Regular physical activity also boosts metabolism, aiding in more efficient fat and calorie burning, which can help you lose weight and complement the weight loss effects of Semaglutide.

Does Semaglutide make you tired?

Techniques to reduce stress and improve sleep quality

Reducing stress and enhancing sleep quality can also aid in managing fatigue associated with Semaglutide. Some techniques that can help include:

  • Deep breathing.
  • Meditation.
  • Yoga.
  • Tai chi.

These stress management techniques can promote better sleep quality for individuals on Semaglutide.

Engaging in activities that bring joy, such as spending time with loved ones, reading, or pursuing hobbies, can also reduce stress and potentially improve sleep quality. It’s important to note that changes related to Semaglutide usage, such as increased agitation and irritability, can indirectly affect sleep patterns, thus contributing to fatigue.

Addressing concerns: When to seek medical attention

Even though the body can adapt to Semaglutide and there are strategies to manage its side effects, if fatigue lingers or intensifies, seeking medical attention is of utmost importance. If fatigue persists for longer than a month after starting Semaglutide, a consultation with a doctor is advised.

Additionally, if the most common side effects persist after six months, it’s important to discuss with a healthcare provider the possibility of adjusting the dosage or discontinuing Semaglutide treatment. Also, seek immediate medical attention if experiencing any serious side effects from Semaglutide, such as severe allergic reactions or pancreatitis.

The significance of personal health goals and medical history

When managing Semaglutide treatment, one’s personal health goals and medical history should never be sidelined. The occurrence of fatigue and other side effects can be impacted by:

  • The individual’s starting weight.
  • Comorbidities.
  • Other medications.
  • Lifestyle choices.
Does Semaglutide make you tired?

Navigating dosage and administration

Achieving the optimal balance in Semaglutide dosage and administration can aid in mitigating side effects such as fatigue. Starting with a low dose and slowly increasing the dosage may reduce the risk of side effects. This approach, known as ‘start low and go slow,’ is often used during the dose-escalation phase of Semaglutide treatment.

Proper administration of Semaglutide is crucial. For example, taking the oral form (Rybelsus) on an empty stomach with water before food can ensure maximum absorption and therapeutic effectiveness. The appropriate dosage of Semaglutide is determined by individual factors such as age, BMI, medical history, blood sugar levels, and concurrent medications.

The connection between dosage and fatigue

The severity of side effects can be influenced by the dosage of Semaglutide. Individuals who take a higher dose of Semaglutide may experience the following side effects:

  • Feeling tired.
  • Nausea.
  • Diarrhea.
  • Vomiting.
  • Abdominal pain.
  • Decreased appetite.
  • Headache.
  • Dizziness.
  • Constipation.

This feeling of tiredness is often correlated with the higher dosage of the medication.

Starting on a low dose and increasing it gradually may help reduce the risk of side effects like fatigue, according to clinical experience. This approach allows the body to adjust more gradually to the medication.


In conclusion, while Semaglutide can make you tired, there are strategies to manage this side effect. From understanding how the medication works, to making lifestyle modifications, to seeking regular medical attention, each step helps in optimizing your Semaglutide treatment. Always remember, your health journey is a marathon, not a sprint. Take one step at a time and consult your healthcare provider to navigate any hurdles along the way.

Frequently asked questions

Does Semaglutide give you energy?

No, Semaglutide is not known to directly provide an energy boost or increase alertness like stimulants or caffeine.

How does Semaglutide make you feel?

Semaglutide for weight loss may cause other common side effects like dizziness, fatigue, and gastrointestinal issues like diarrhea, constipation, and gassiness. Be mindful of these potential side effects.

Does Semaglutide affect sleep?

Semaglutide affects sleep and other similar drugs may help promote better sleep by reducing alcohol and nicotine use, which can interfere with sleep. This is due to the activation of GLP-1 and GIP receptors.